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ǥ : ȣ - 530934   159 
Uncovered ostial area gives in-segment restenosis in percutaneous coronary intervention of proximal stenosis with mild ostial involvement.
가톨릭대학교 의과대학 순환기내과
추은호, 승기배, 서석민, 김지희, 엄재선, 고윤석, 정우백, 박만원, 윤성규, 박훈준, 김범준, 정해억, 장기육, 오용석, 백상홍, 정욱성
Backgrounds: When stenting in the proximal stenoses with mild ostial involvement, few studies to directly compare the long-term outcomes of ostial coverage have been performed. Methods: We reviewed consecutive 59 patients with proximal part stenosis at any coronary arteries. Each lesion has a mild ostial lesion and a distal tandem severe stenosis. All patients underwent follow-up coronary angiography when the patient has chest pain and at 9 month to 1 year after index PCI. Primary outcome was restenosis at proximal edge of the stent. Results : For 29 patients ostiums were covered by stent (covered group, 49.2%), stent was not covered at ostium for 30 patients (uncovered group, 50.8%). All patients were implanted with sirolimus-eluting stent (n=34) or paclitaxel eluting stent (n=25) (57.6% vs 42.4%). There was no difference with baseline characteristics between covered group and uncovered group. After follow-up period (387±263 days), 7 patients developed restenosis in uncovered group, 1 patient did in covered group (23.3% vs. 3.4%, p=0.026). Uncoverage of ostium was a single independent risk factor for proximal edge restenosis (Adjusted hazard ratio[HR] = 9.392, 95% confidence interval [CI] : 1.095 to 80.582, p=0.041). Of enrolled lesions, left anterior descending artery (LAD) was dominant (n=32, 54.2%). Proximal edge restenosis occurred in 5 patients with proximal stenosis at LAD and 3 patients with stenosis at right coronary artery (15.6% vs. 15%). Conclusion : Ostial coverage is very important to prevent proximal edge restenosis in patients with proximal severe stenosis with mild ostial involvement during PCI.

 

Multivariate Cox regression analysis for proximal edge restenosis

 

Hazard ratio

95% confidence interval

P value

Sirolimus eluting stent

0.513

0.117-2.253

0.376

Stent diameter

0.996

0.112-8.901

0.997

Diabetes

0.117

0.013-1.040

0.054

Ostial coverage

9.392

1.095-80.582

0.041

 



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