Purpose: Despite the availability of effective primary and secondary therapies, atherosclerotic coronary artery disease (CAD) remains the leading cause of morbidity and mortality. Traditional cardiovascular risk factors such as hypertension(HTN), diabetes mellitus(DM), and smoking predict less than one half of cardiovascular events. And the presence of coronary plaque is recently known to be independent and incremental to traditional risk assessment for the prediction of cardiovascular events. We evaluated the association between cardiovascular risk factors and extent of atherosclerotic CAD. Methods: We studied 1,814 patients (817 males and 997 females aged 61.7짹12.3 years) with known or suspected CAD undergoing 64-slice MDCT. The patients had no prior history of revascularization. Coronary arteries without plaque were considered normal. The severity and extent of CAD, plaque of coronary arteries and clinical and laboratory parameters were analyzed. Results: Among the 1814 patients, 904 patients (15.8 %) had CAD, 391 patients (21.6%) had obstructive CAD (> 50% luminal stenosis). In patients with CAD, numbers of segment with plaque was 3.4짹2.1, was significantly associated with HDL (odds ratio 3.7,p=0.00), apo B(odds ratio 2.0, p=0.04). On multivariate logistic regression analysis after adjustment age, sex, and tranditional risk factors, significant clinical predictor of CAD was diabetes (DM), hypertension(HTN), prior cerebrovascular attack (CVA), HDL, apo B (p <0.05). The predictors of obstructive CAD was DM, HTN, HDL, apoB (p<0.05). Conclusions: Our data suggest that tranditional clinical risk factors and laboratory parameters might be associated with the severity and extent of CAD, plaque of coronary arteries