Background竊�Endovascular therapy (EVT) is considered as an effective treatment in pts with chronic total occlusion (CTO) lesion in ilio-femoral artery. Recently, subintimal angioplasty (SA) has been widely spread technique for the iliofemoral CTO recanalization but there are still controversies in SA outcomes. Method: A total of128 consecutive pts who had significant iliofemoral arterial disease underwent EVT between 2004 and 2008. Out of 128, 37 pts with iliofemoral CTO lesion were treated by SA. If the culprit lesion was not well-maintained after the ballooning, subsequent self-expanding nitinol stents were deployed. We report the overall success rate, periprocedural complications and mid-term clinical outcomes. Results: The baseline characteristics of the 37 pts with 280 lesions who underwent iliofemoral SA showed that the mean age was 67.3 짹 9.1 years old, 30 (81.1%) pts were male, and 32 (61.1%) pts were current smokers. The procedural successful rate was very high (278 /280 limbs, 99.3%) without serious periprocedural complications. There were only two target vessel revascularizations without death, and major amputation up to 6 months(Table). Conclusion: SA for iliofemoral CTO pts was very safe and showed excellent procedural success rate without significant periprocedural complications with excellent limb salvage. Long-term follow up with larger population will be necessary to elucidate the final conclusion.