Percutaneous cardiopulmonary support (PCPS) has the potential to rescue patients in cardiac arrest who might otherwise die. However, the indication for deployment and prognostic factor of PCPS apply has not yet established. We reviewed a single center experience with performing PCPS to patients with severe cardiopulmonary failure and prognostic factor of survival. METHOD : From June 2008 to July 2009, PCPS had been applied to 10 patients (5 male), 5 cases were acute myocardial infarction with cardiogenic shock, 2 cases of pulmonary embolism, 2 cases of chronic heart failure with ventricular tachycardia, 1 case of septic shock with impaired oxygenation. An intraarotic ballon pump and continuous hemodiafilteration was added on cases of 6 (60%) and 5 (50%) patients, respectively. Mean duration of PCPS was 122 짹 73 hours. In 4 cases, PCPS could be weaned off and those patients were survived. Six cases, could not be weaned PCPS or could be weaned off, but were expired in several days. In 4 survivor group, mean age was 66.5 짹 18.3 years and 2 cases were age over 80, mean duration of PCPS was 72 짹 19 hours, 3 cases were cardiogenic shock, 1 case was ventricular tachycardia. In the expired group, mean age was 64.1 짹 6.3 years, mean duration of PCPS was 156 짹 86 hours, 2 case were pulmonary embolism, 2 cases were cardiogenic shock, 1 case was ventricular tachycardia with CHF, 1 case was septic shock. Conclusion: In this data, causing disease of severe cardiopulmonary failure and duration of PCPS seem to be more valuable prognostic factor. In old age group PCPS can be a useful rescue treatment also even in octagenarian.