Backgrounds: Planned follow-up coronary angiography (F/U CAG) led to a 1.7 times higher reintervention rate compared to ischemic-driven F/U CAG in bare metal stent era. However, it is still unclear whether planned F/U CAG after percutaneous coronary intervention (PCI) with drug eluting stent (DES) influences late outcome. Objective: This research was to study the effect of planned F/U CAG vs. ischemic-driven F/U CAG on late clinical outcome after PCI with DES. Methods: From November 2004 through December 2008, a total of one hundred patients (M:F=55:45, mean age=65.4짹11.9) were enrolled among the 473 patients undergone PCI and F/U CAG. The patients were divided into two groups; planned F/U CAG group (group 1, n=87, M:F=49:38, mean age=65.0짹12.4) vs. ischemic-driven F/U CAG group (group 2, n=13, M:F=6:7, mean age=67.9짹7.2). Planned F/U CAG was defined as CAG without angina and ischemic-driven F/U CAG was defined as CAG performed due to recurrent angina. We compared major adverse cardiac events (MACE) and reintervention rate between both groups. Results: There were no significant differences in clinical and angiographic characteristics between both groups. The mean follow-up duration was 256짹142 days in group 1 and 354짹326 days in group 2 (p=0.302). The rate of MACE in group 2 was higher than the group 1 (64.3% vs. 19.8%, p=0.001) (see Table). Reintervention rate in group 1 was higher than group 2 (53.8% vs. 20.7%, p=0.01). But the all cause mortality was not different between two groups. Conclusions: Planned F/U CAG reduces the incidence of MACE and leads to an increased reintervention rate compared with ischemic-driven F/U CAG.

	Group 1	Group 2
	(Planned F/U CAG)	(Ischemic-driven F/U CAG)	p Value
	n=87	n=13
Major adverse cardiac events	17 (19.5%)	8 (61.5%)	0.001
Death	0 (0)	0 (0)	NS
Myocardial infarction	0 (0)	0 (0)	NS
TVR	4 (4.6%)	0 (0)	NS
TLR	8 (9.2%)	3 (23.1%)	NS
Non-culprit TVR	5 (5.7%)	5 (38.5%)	NS

TVR; target vessel revascularization, TLR; target lesion revascularization