Background: The coronary artery calcium score (CACS) on cardiac computed tomography (CT) is reported to represent total burden of coronary atherosclerotic changes and its prognostic value has been being tested in various disease. Although there is a hot debate regarding potential association between atherosclerosis and degenerative aortic valve sclerosis or development of aortic stenosis, the relationship between CACS and morphologic changes of aortic valve has not been seriously investigated. Method: Clinical data of 1,025 subjects (687 males, age 59짹10 years), who underwent both echocardiography and cardiac CT for routine annual medical examination without subjective symptoms, were analyzed. The morphologic changes of each aortic valve cusp on echocardiography was scored for cusp thickeness, calcification and degree of motion limitation; total score of 3 cusps (AVSS) was used as aortic valve sclerosis score (0-9 points). Subjects were divided into four groups according to their CACS (group 1; CACS=0, group 2; 0<CACS���100, group 3; 100<CACS���300, group 4; 300<CACS). Result: CACS showed positive correlation with AVSS (rho=0.217, p<0.001, figure). Age showed positive correlation with both CACS and AVSS (rho=0.298 and 0.366 respectively, p<0.001). In multivariate analysis using proportional logistic regression analysis, AVSS was not an independent variable associated with CACS. Conclusion: In this cross-sectional study using cardiac CT and echocardiography, significant independent association between degree of atherosclerosis and morphologic changes of aortic valve could not be confirmed. A longitudinal follow-up study is necessary for further evaluaion of their relationship.