Background: Hyperuricemia and anemia have been known to be prognostic markers in patients (pts) with heart failure. Then we investigated incremental prognostic value of these parameters in pts with acute heart failure (AHF). Methods and Results: We analyzed baseline laboratory findings and echocardiographic parameters in 195 hospitalized AHF pts (101 males, 65.3 짹 14.4 years old). Cardiovascular (CV) events were defined as 1-year cardiovascular (CV) mortality and/or heart failure rehospitalization. Hyperuricemia was defined as uric acid > 7 mg/dl in male, > 6 mg/dl in female and anemia was defined as hemoglobin (Hb) < 13 mg/dl in male, < 12 mg/dl in female. In our study, mean uric acid was 7.4 짹 6.4 mg/dl and mean Hb was 12.3 짹 2.3 mg/dl. Median NT-proBNP was 5589 (IQR 2264-13657) pg/ml and mean LV ejection fraction (LVEF) was 32.5 짹 15.0 %, respectively. During follow-up (median 360 days), 28 pts (14.4%) died and 74 pts (37.9%) were rehospitalized. The Kaplan-Meier analysis revealed that the pts with both anemia and hyperuricemia had a higher CV events compared with the pts with either anemia or hyperuricemia (69.2% vs 48.2% or 56.5%, log-rank: p = 0.009). Combined finding both hyperuricemia and anemia was an independent predictor of CV events after adjusting age, sex, LVEF, estimated glomerular filtration rate and log NT-proBNP level (hazard ratio : 3.075, 95% CI 1.455-6.500, p = 0.003) in Cox proportional hazard analysis. Conclusion: We found that incremental prognostic value of hyperuricemia and anemia in pts with AHF and its prognostic power for predicting CV events was independent of other cardiovascular risk factors in these pts.