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ǥ : ȣ - 530810   390 
DIFFERENT TREATMENT STRATEGY IN VENOUS THROMBOEMBOLISM IN PREGNANCY
관동의대 제일병원
원현선, 양문석, 박정배
Background/Aims: Venous thromboembolism (VTE) in pregnancy is a major cause of fatal maternal complication and death, but the risk is still inconclusive. Therefore, this study was to estimate the follow-up cardiovascular events depending on treatment of VTE in pregnancy. Methods: We retrospectively evaluated the risk factors and treatment for objectively verified VTE during pregnancy or postpartum in 56,989 deliveries for 7years at Cheil General Hospital, Kwandong University College of Medicine. Results: The incidence of VTE was 0.047% (27 patients, mean age 32.1±2.9 years), deep venous thrombosis [DVT] 0.012% (7 patients) and pulmonary embolism [PE] in 0.043% (20 patients). The incidence of DVT was higher in antenatal period and that of PE was higher in postnatal period (chi-square 9.3, p<0.01). Most cases showed clinical improvement spontaneously or with anticoagulation and surgical thrombectomy, except one fatal case due to massive PE. In patients of VTE, 61 % of patients received a short-term treatment of heparin (<7 days) and only 35% received a short term treatment of warfarin (<2weeks). However, there was no difference of age, incidence of gestational diabetes or hypertension, delivery type, development of pulmonary hypertension, severity of PE, and follow-up events to 6 months in patients with or without heparin or warfarin treatment. Conclusions: In contrast to known treatment of PE in pregnancy, our experience shows no benefit of anticoagulation therapy in clinically stable conditions, which may need a different treatment strategy in patients in pregnancy from non-pregnant patients.


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