Backgrounds : High level of high sensitivity C-reactive protein(hsCRP) is known to be associated with increased coronary events and poor prognosis in acute myocardial infarction. We studied whether mid-term follow-up hsCRP (f/u hsCRP) after percutaneous coronary intervention(PCI) is associated coronary events and prognosis or not. Methods : In this single-center retrospective cohort study, 763 patients, who underwent PCI, were estimated f/u hsCRP after 4 month. We compared group A (f/u hsCRP ��� 0.5, N=677) with group B (f/u CRP> 0.5, N=86). Major adverse cardiac events(MACE) were associated at 2 years after the procedure. The cutoff point of hsCRP was normal range of our hospital. Results : Group B had more elderly patients (61.4짹10.2 vs. 65.5짹10.1, p=0.001), higher serum creatinine (1.2짹1.1 vs. 1.5짹1.4, p=0.044), lower body mass index (24.6짹3.0 vs. 23.8짹3.2, p=0.027) and lower ejection fraction (55.8짹11.8 vs. 52.3짹13.7, p=0.026). One year MACE, all cause of death, myocardial infarction and 2 year MACE, all cause of death were higher in group B. Multivariate analysis disclosed that f/u hsCRP and serum creatinine were a significant independent predictor of 1 year MACE and 2 years MACE. Conclusions : Therefore elevated mid-term f/u hsCRP level in patients who underwent PCI seems to be a good valuable factor for the long term outcomes.