Background: Stent thrombosis (ST) is very rare but can be a devastating complication in the drug-eluting stent (DES) era. DES ST is known to be associated with a variety of factors and eliminating predictors may contribute better prognosis. This study is to evaluate predictors attributable to DES ST in a series of Asian population up to 5 years. Methods: A total of 2058 consecutive patients (pts) undergoing percutaneous coronary intervention (PCI) with DESs were enrolled and divided into two groups according to presence of angiographic ST (ST: n=30 pts , non-ST: n=2028 pts). ST was defined according to ARC definition as acute (< 24 hours), subacute (24 hours to 30 days), late (>30 days to 1 year), or very late (>1 year) ST. Results: The baseline characteristics were similar between ST and non-ST groups except ST elevation myocardial infarction (STEMI) was higher in ST (4.9% vs 1.2%, p<0.01). Overall DES ST was 1.48% (30/2058), acute 0.10% (2), subacute 0.35% (7), late 0.30% (6) and very late ST 0.73% (15, 12 pts up to 3 year, 3 pts between 3-5 years). At index procedure, maximal balloon inflation pressure was higher (14.2 짹 5.6 mmHg vs 13.7 짹 6.1 mmHg, p=0.05), and balloon inflation duration was shorter in very late ST group (12.6 짹 4.8 sec vs 13.6짹6.1 sec, p=0.05). Out of 15 pts in very late ST, DES type was not different (Cypher; 8 pts, Taxus; 7 pts). Discontinuation of aspirin and clopidogrel were associated with subacute, late and very late ST. STEMI was an independent predictor of subacute (hazard ratio [HR]: 6.36, 95% confidence interval [CI] 1.36 to 28.8, p=0.02) and very late ST (HR: 3.73, 95% [CI] 1.07 to 12.9, p<0.01). Discontinuation of clopidogrel was an independent predictor of very late ST (HR: 55.8, 95% [CI] 8.6 to 36.1, p<0.01) Conclusion: Higher maximal balloon inflation pressure and shorter inflation duration may impact on the ST development. Presentation with STEMI and discontinuation of clopidogrel were associated with subacute and very late ST.