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ȣ - 530458 414 |
| Effect of Administration of Neu2000 on Ischemic Reperfusion Injury and Left Ventricular Remodeling in a Porcine Model of Acute Myocardial Infarction |
| 전남대학교병원 심장센터1, 고려의대 안산병원2, 전남대학교병원 핵의학과3, 뉴로테크4 |
| 홍영준1, 정명호1, 심두선1, 임상엽2, 김정하1, 임경섭1, 송호천3, 민정준3, 범희승3, 박의진4, 조성익4, 문경준4, 곽병주4, 고점석1, 이민구1, 박근호1, 심두선1, 윤남식1, 윤현주1, 김계훈1, 박형욱1, 김주한1, 안영근1, 조정관1, 박종춘1, 강정채1 |
BACKGRUND: 2-hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)-benzoic acid (Neu2000) is a rational therapeutic drug derived from sulfasalazine, a conjugate of 5-aminosalicylic acid and sulfapyridine designed to protect neurons from oxidative stress in the central nervous system.
OBJECTIVES: The aim of this study was to examine the effect of administration of Neu2000 on ischemic reperfusion injury and left ventricular remodeling in a porcine model of acute myocardial infarction.
METHODS: Acute myocardial infarction was made by balloon occlusion (3.0*20mm) in middle left anterior descending artery for 35 minutes. Neu2000 (n=18) and control saline (n=20) was infused via intravenous route for 15 minutes from 20 minutes to 35 minutes after balloon occlusion in each group. Myocardial SPECT was checked at 1 day and after 28 days after the completion of experiment.
RESULTS: There were no significant differences in the mortality rate after the completion of the experiment and the incidence of the development of ventricular tachyarrhythmia during and after infusion of Neu2000 or control saline between the two groups (50%, 61% in Neu2000 group vs. 65%, 70% in control group, p=0.350, p=0.564, respectively). We can obtain baseline (1 day) and follow-up SPECT (28 day) data in 9 pigs in Neu2000 group and 7 pigs in control group. Baseline ejection fraction was significantly higher (48±9% vs. 37±12%, p=0.047) and there were trends toward lower left ventricular end systolic and diastolic volumes (21±8ml vs. 38±24ml, p=0.066, and 39±9ml vs. 59±31ml, p=0.098) in Neu2000 group compared with control group. At 28 days, there were trends that the increases of left ventricular end systolic and diastolic volumes were smaller (△=+20±11ml vs. +60±40ml, p=0.085, and △=+41±13ml vs. +76±38ml, p=0.058) and the decrease of ejection fraction was smaller (△=+0.33±6.06% vs. -7.80±11.52%, p=0.166) in Neu2000 group compared with control group.
CONCLUSIONS: The administration of Neu2000 may reduce the ischemic reperfusion injury and left ventricular remodeling in a porcine model of acute myocardial infarction.
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