Background and objectives: Stress induced cardiomyopathy (SCM) due to underlying severe medical disorders is not well recognized. Thus, we sought to assess the clinical and echocardiographic features of SCM patients in medical ICU. Methods: We analysed 27, who fulfilled the following criteria: 1) transient wall motion abnormalities 2) no significant coronary stenosis 3) no known reversible cardiomyopathies Results: Of 27 patients (61 짹 14 years), 16 (59 %) were women. Underlying medical disorders were severe infection/inflammation (n=16), sepsis (n=7), and bronchial asthma (n=4). Hypoxia on blood gas analysis was documented in 17 (63%) patients. Invasive coronary angiography was done in 7 patients. Chest symptoms were found in 14 (52%) patients. Electrocardiographic changes were found in 26 patients (ST elevation [n=8], ST depression [n=6], Q wave [n=2], T inversion [n=14]). Troponin-I was elevated in 24 patients with peak level of 4.0 짹 3.6 ng/mL. Left ventricular ejection fraction was improved from 32 짹 8% (initial) to 60 짹 8% (follow up). Left ventricular wall motion showed segmental (n=17) and global (n=10) abnormalities. Conclusion: Trigger-related typical SCM patients have almost regional wall motion abnormalities, predominantly in apical segments, however, considerable number of SCM patients with underlying medical illness showed global hypokinesia. Thus, the presence of the transient global hypokinesia as well as segmental wall motion abnormalities in patients with severe medical disorders could reflect stress-induced cardiomyopathy.