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The Registry of Korean Atrial Fibrillation (KORAF): Patient characteristics and outcome of stroke prevention
고려대학교 안암병원 순환기내과, KORAF investigator
김영훈, 노태호, 오용석, 이영수, 조용근, 차태준, 곽충환, 오동진, 최인석, 이명용, 박상원, 오세일, 김준수, 신동구, 이문형, 최기준, 김남호, 김대경, 남궁준, 김대혁, 조정관, 이경석, 이재환, 조명찬, 김윤년
KORAF (KORean Atrial Fibrillation) is the prospective study registered electrocardiographically confirmed AF patients who firstly diagnosed at each institute since 2006 and followed up for at least 1 year. Methods: This study is to perform nondirected follow-up to evaluate the clinical course and outcomes of AF. Overall 3,813 patients were enrolled at 27 hospitals in 13 cities of South Korea. A set of standardized data forms were used to obtain clinical information. Follow-up investigations were performed at 1 year. Results: Clinical type of AF was paroxysmal in 43%, firstly detected in 24%, permanent in 14%, and persistent in 12%. 5 major risk factors of AF were hypertension (38.5%), sleep disorders (16.2%), smoking (14.4%), diabetes (13.7%), and congestive heart failure (CHF, 12%). 3 major precipitating factors were mental or psychic stress (14%), alcohol (6%), and sleep apnea (3%). Alcoholic drinking in patients with AF was significantly associated with new onset of AF in ages < 50 years. Older age (>75 yrs, 24%), valvular diseases (17%), diabetes mellitus (12%), history of cerebral thromboembolism (TE, 11%), CHF (8%), and myocardial infarction (5%), who were at particular risk for TE, were fewer than those with low risk, therefore, warfarin was underused (881, 37.5%) and aspirin was more commonly prescribed (1,470, 62.5%). The rhythms at 1-year follow-up were AF in 51% (n=413), normal sinus rhythm in 43% (n=343), and atrial flutter in 2% (n=13). Transient ischemic attack or ischemic TE was developed in 0.7% (n=20). 1.7% (n=46) were died during follow-up. Warfarin did not change 1-year mortality, but aspirin improved survival in this population (OR 0.398, p<0.05). Conclusion: Alcoholic drinking was significantly associated with new onset of AF in younger patients (< 50 years). In this population including relatively younger and paroxysmal AF group, warfarin was underutilized, instead a high percentage were prescribed aspirin, which significantly improved survival.


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