Background: Safety and feasibility of Ergonovine Stress Echocardiography (erg echo) has been discussed by a few authors for years. To encourage erg echo in the clinical field, much larger data is needed. Subjects and Method: From November 2002 to June 2009, we retrospectively analyzed the consecutive 3094 erg echo data. Results: Among 3094 cases (1767 males with 50짹12 years, 1327 females with 53짹11 years), 8.3% (257) showed positive results with RWMAs and/or ECG change. There was no procedure-related death or development of myocardial infarct. Transient adverse events were reported in 0.55%(17/3094), including AV block(9), sinus bradycardia(4), paroxysmal atrial fibrillation(2), wide QRS tachycardia(1), syncope(1). But, these adverse events were completely recovered with intravenous nitroglycerin and sublingual nifedipine. Chest compression was needed in only one case of 47 year old woman who developed complete AV and shock. She recovered in a few minutes. Variant angina was the most frequent referral diagnosis for the test and atypical chest pain was the second (75.7% vs. 16.2% ; p<0.0001). Among 257 positive erg echo cases, 44.7%(115) were provocated at 150ug, 53.3%(137) were at 350ug. There were 204 males and 53 females in the positive erg echo(79.4% vs. 20.6% ;p<0.0001). Incidence of positive erg echo was 23%(60) in the age 40-49 group, 35.8%(92) in the age 50-59 group, 24.1%(62) in the age 60-69 group, and 12.8%(33) in over the age of 70 group. Conclusions: Erg echo is very safe with low adverse events and highly feasible for detection of coronary vasospasm.