Background: This study examined the significance of preprocedural neutrophilia with anemia in clinical outcomes after percutaneous coronary intervention in patients with ST-elevation myocardial infarction. Methods: We analyzed data from 699 eligible patients undergoing a 1-year follow-up after PCI for ST-elevation myocardial infarction from Oct 2005 and Jan 2008. The study population was categorized according to the neutrophil count (the 1st, 2nd and 3rd tertile; < 6,260, 6260-9499 and ���9,500/mm3) and hemoglobin level (Hb ��� 12, 10 ��� Hb < 12 and Hb < 10) on admission. We scored the patients one after the other according to the neutrophil count (the 1st, 2nd and 3rd tertile; 0, 1 and 2) and hemogolin level(Hb ��� 12, 10 ��� Hb < 12 and Hb < 10 mg/dL; 0, 1 and 2). And, total patients were divided into five groups based on the sum of each score (0, group I, n=178 ;1, group II, n=225 ;2, group III, n=236 ;3, group IV, n=40 ;4, group V, n=20). Results: The mean values of neutrophil count and hemoglobin level were 8490 짹 3860 /mm3 and 13.61 짹 1.94 mg/dL respectively. Patients with neutrophilia (neutrophil > 7,260/mm3) and anemia (Hb <12 mg/dL) were 107 patients (15.3%). They were older, had more comorbidities, had lower creatinine clearance, and had higher high-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide levels. Group IV and V had significant higher 1-month major cardiac events (6% vs. 25% vs. 35%, p<0.001) and 12-month death (8% vs. 30% vs. 35%, p<0.001) compared with group I. In a multivariable setting, after adjusting for standard risk factors for ST-elevation myocardial infarction, the coexistence of preprocedural neutrophil count in the third tertile and hemoglobin level less than 10 mg/dL were independent predictors of 1-month major adverse cardiac events (OR, 4.66; 95% CI, 1.153-18.826; P = 0.031), but not of 12-month mortality. Conclusion: The coexistence of preprocedural neutrophilia and anemia in patients undergoing PCI for ST-elevation myocardial infarction is an independent predictor of short-term clinical outcomes.