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Metabolic Risk Factor and Target Organ Damage were More Frequent in Masked Hypertension Than White Coat Hypertension
전남의대¹, 관동의대², 고려의대³, 카톨릭의대⁴, 서울의대5, 아주의대6, 충북의대7, 연세의대8, 건양의대9, 한국보건원10
윤현주¹, 안영근¹, 박정배², 박창규³, 윤호중⁴, 최동주5, 신준한6, 김동운7, 임세중8, 배장호9, 박현영10 on behalf of Korean Hypertension Network
Background: Patients with masked hypertension tend to have a higher risk than white coat hypertension. But there are few data showing the real characteristics. Therefore, we evaluated the characteristics of masked hypertension in patients receiving medical treatment for hypertension. Methods: We enrolled 1,021 out-patients (mean age: 56±10 years, 488 males) with diagnosed of hypertension who did not change oral anti-hypertensive medication for 6 months. Office BP (blood pressure) was checked by nurse and doctor twice per visit. Home BP was checked in every morning and evening for 2 weeks. We compared the characteristics between masked hypertension and white coat hypertension patients group. Results: There were 107 (10.5 %) patients with masked hypertension, and 236 (23.1 %) patients with white coat hypertension. Mean office BP was 130/80 mmHg, whereas home BP was 137/86 mmHg in masked hypertension. In white coat hypertension, mean office BP was 149/86 mmHg and mean home BP was 124/75 mmHg. Age and gender was not differet between two groups. Body weight (68±10 vs. 65±10 kg), body mass index (25±3 vs. 24±3), waist (89±9 vs. 86±9 cm) and hip circumference (99±6 vs. 97±6 cm) were higher in masked hypertension group. Fasting blood sugar level was higher in masked hypertension group (112±37 vs. 104±16 mg/dL, p=0.009). Family history of premature cardiovascular death (p=0.02) and heart damage (p=0.03) such as left ventricular hypertrophy, angina, prior myocardial infarction and heart failure were more frequent in masked hypertension group. Angiotensin converting enzyme inhibitor (p=0.01) and alpha blocker (p=0.02) were more commonly used in masked hypertension group, whereas beta blocker (p=0.02) in white coat hypertension group. Conclusion: Metabolic risk was more closely related with masked hypertension than white coat hypertension. Home BP measurement was an useful tool of discrimination of masked hypertension in patients with hypertension.


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