Background: Acute ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) have different therapeutic strategies. The aim of this study is to assess risk factors, therapeutic strategies, clinical outcomes, and prognostic factors of STEMI and NSTEMI. Methods: The patients admitted in our hospital with a diagnosis of acute MI between November 2005 and December 2006 were evaluated. We analyzed baseline clinical characteristics, angiographic characteristics, in-hospital mortality, and major adverse cardiac events (MACE) during clinical follow-up for one year in patients with STEMI and NSTEMI patients. Results: 447 patients were STEMI and 186 patients were NSTEMI. Smoking was the most common risk factor in both group. Primary percutaneous coronary intervention (PCI) was performed in 85.0 % and thrombolysis was performed in 7.2% in STEMI group. Early invasive strategy was chosen in 66.7 % in NSTEMI group. The rate of in-hospital mortality was 3.8 % in STEMI group and 3.2 % in NSTEMI group. The rates of MACE at 6-months and 1-year were not significantly different between both groups (17.7 % vs 17.3 % and 22.8 % vs 20.2 %). Diabetes mellitus, smoking, and left ventricular ejection fraction (LVEF < 40 %) on admission, and serum troponin I in STEMI group and diabetes mellitus, smoking, and LVEF < 40 % on admission in NSTEMI group were independent predictors of prognosis. Troponin I was the only predictor of prognosis in STEMI group (p=0.047 vs p=0.139). Conclusion: The patients with STEMI and NSTEMI have similar clinical outcomes during one-year clinical follow-up. Among the predictors of prognosis, troponin I is the only one in STEMI.