Background: Myocardial bridge (MB) is common finding in coronary angiogram (CAG). It is known harmless but may cause angina pectoris, myocardial infarction, life threatening arrhythmia and even sudden cardiac death. We studied long-term clinical course of patients in who have MB without critical stenosis in CAG. Also, we investigated the predictor of rehospitalization and the subsequent management in these patients. Methods: We reviewed the chart of 7,869 patients who undergone angiography because of chest pain from January 2005 to May 2008. Total 308 patients (168 males, 57.5짹 10.6 years) who had MB (with >50% systolic lumen diameter reduction) with persistent chest pain and no obstructive coronary artery disease (defined as <50% stenosis in >1 major coronary artery) were enrolled. The patients with risk factor causing chest pain (ex: valvular heart disease, cardiomyopathy, pulmonary disease, gastrointestinal disease) were excluded. Clinical characteristics, electrocardiogram, coronary angiogram, echocardiography, and laboratory examination were evaluated. Clinically the patients were followed up with respect to rehospitalization after the baseline CAG. End point of this study was rehospitalization due to chest pain refractory to medical therapy, myocardial infarction, life threatening arrhythmia and cardiac death. Results: At a mean follow-up of 56 months, rehospitalization had occurred in 58 patients (19.0%) including 49 (16%) patients with chest pain refractory to medication, 7 (2.3%) myocardial infarctions, 1 (0.3%) life threatening arrhythmia and 1 (0.3%) sudden cardiac death. In Cox regression analysis, long segment of MB (HR; 2.780 95% CI= 1.070-7.218, p= 0.036), documented vasospasm in CAG (HR; 2.335 95% CI=1.055-5.171 p=0.037) were independent predictors of rehospitalization after adjustment for clinical, angiographic and procedural data. The additional use of aspirin or statin lowered rehospitalization (HR: 0.247 95% CI 0.109-0.560 p<0.001), (HR=0.455, 0.218-0.950 p=0.036). Conclusions: MB with non-occlusive CAG is not bengin and recurrent hospitalization is common. The patients with long segment MB or documented spasm in CAG need intensive medical therapy.