Background: Contrast-induced nephropathy (CIN) is an important complication after percutaneous coronary intervention (PCI), resulting in prolonged hospitalization and increased in-hospital and long term morbidity and mortality. Methods: From October of 2006 to December of 2008 we retrospectively evaluated the clinical, laboratory and angiographic data of 985 patients who had undergone PCI at the Soonchunhyang university cheonan hospital. Results: 35 (3.6%) of 985 patients experienced CIN after PCI. In mulivariate analysis, eGFR ���60 ml/min/1.73 m, hypoalbuminemia, acute myocardial infarction are risk factors for CIN. In univariate analysis, age, diabetes mellitus, fasting blood sugar, anemia, hyperuricemia, high glycated hemoglobin are possible risk factors for CIN. The subgroup with diabetes mellitus and eGFR rate ��� 60 ml/min/1.73 m have a 14.5-fold increased risk for CIN than the subgroup without diabetes mellitus and eGFR > 60 ml/min/1.73 m (OR 14.500; 95% CI 5.355-39.264; p < 0.001). Diabetes mellitus is not a risk factor for CIN in the setting of subgroup with eGFR > 60 ml/min/1.73 m (OR 1.312; 95% CI 0.325-5.295; p = 0.703). Conclusion: The overall incidence of CIN is 3.6%. In our data, eGFR ��� 60 ml/min/1.73 m, hypoalbuminemia, acute myocardial infarction are risk factors for CIN. The patients with diabetes mellitus and estimated glomerular filtration rate ��� 60 ml/min/1.73 m have a highly risk for CIN.