Background: There is little data regarding the NSD and intimal hyperplasia(IH). The aim of this study was identify the impact of nonuniform strut distribution(NSD) on intimal hyperplasia in patients with drug eluting stent(DES) implamtation. Methods: From January 2006 to May 2007, patients having IVUS guided intervention with DES implantation were consecutively registered. NSD was defined as interstrut angle > 90째, and NSD segment was defined as any segment observed for more than 0.5 mm longitudinally. Lesions were graded as follows: grade 1, none or slight intimal proliferation(���25%); grade 2, intimal proliferation with no significant stenosis (<50%); grade 3, intimal proliferation with moderate stenosis (���50%); and grade 4, intimal proliferation with severe stenosis (���75%). Grade 2, 3 and 4 were considered IH, and Grades 3 and 4 were considered binary instent restenosis(ISR). NSD after stent implantation and followed intimal hyperplasia were assessesd. Results: We performed IVUS in 120 patients after stent implantation, and 123 stented lesions were scanned. Of these, 71 (59.2%) had follow up analysis for intimal hyperplasia. The IH was more frequenty occur in NSD patients(with NSD 17.4% vs without NSD 5.2%, p=0.045) and The ISR were more frequently occur in NSD patients without statistical significance(with NSD 15.4% vs without NSD 6.5%, p=0.253). Conclusions: Patients with NSD after DES implantation have an increased IH rate compared to patients without NSD.