Background: Nonuniform strut distribution (NSD) has been shown to be associated with increased intimal hyperplasia after drug-eluting stent(DES) implantation. The aim of this study was to compare the difference of strut distribution among three clinically available drug-eluting stents (Cypher select, Taxus liberte, Endeavor and Xience stents) using intravascular ultrasound (IVUS). Methods: NSD was defined as interstrut angle > 90째, and NSD segment was defined as any segment observed for more than 0.5 mm longitudinally. Percent NSD was defined as the length of segments with NSD divided by stent length. NSD was assessed in post procedure IVUS images in 128 clinical cases (39 Cypher select, 40 Taxus liberte, 21 Endeavor and 25 Xince stents) using 3-dimensional IVUS analysis. Results: Percent NSD was more in Eneavor stent with statistical significance (Cypher select: 0.51% vs Taxus liberte: 0.34% vs Endeavor vs: 1.83% vs Xience 0.69%) and frequency of NSD segment was more in Endeavor and Xience but did not reached statistical significance (Cypher select: 7.5% vs Taxus liberte: 5.0% vs Endeavor: 23.8% vs Xience: 18.5%, P=0.086). Conclusion: Our data shows that there is significant difference in %NSD between four clinically available DES.