Background: The clinical and angiographic outcomes after two or more overlapping sirolimus- and paclitaxel- eluting stents implantation in patients (pts) with diffuse long coronary artery lesions, an important off-label usage of drug-elutng stent (DES) is not clarified yet. Methods: A total of 174 pts who underwent percutaneous coronary intervention (PCI) with overlapping sirolimus- (SES group: Cypher, n=74 pts, 110 lesions) or paclitaxel- eluting stents (PES group: Taxus, n=100 pts, 177 lesions) were enrolled. Angiographic and clinical outcomes at 6 months were evaluated. Results: Both groups had similar baseline clinical and procedural characteristics. At 6 months,PES group showed a trend towards lower minimum lumen diameter (MLD), (2.06짹1.02 vs 2.42짹1.01, P=0.078) compared with SES group. Other angiographic outcomes including binary restenosis, restenosis percentage, and late loss as well as clinical outcomes i.e., cardiac death, Q-wave myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR) and MACE were similar. Conclusions: The angiographic and clinical outcomes at 6 month were similar and favorable in pts with diffuse long lesions undergoing PCI with either Sirolimus- or Paclitaxel- eluting overlapping stenting. Further study with larger study population and longer duration will be needed to get final conclusion.