Background: Cardiac baroreflex sensitivity is widely accepted as a tool for stratifying the risk of mortality and also provides useful information for pathophysiologic mechanism of autonomic nervous system. This study aimed to investigate the impact of age on spontaneous baroreflex sensitivity (SBRS) during orthostatic stress with head-up tilt (HUT) test in healthy subjects. Method: The study population comprised only healthy subjects without a history of syncope and any medical illness. A passive HUT was performed for 60 minutes with FinometerTM. Hemodynamic parameters were simultaneously recorded throughout the test and SBRS was assessed using the sequence method. Result: 80 healthy volunteers participated and 14 subjects showed who showed positive on HUT were excluded. A total of 66 subjects with mean age of 38.9 짹 10.9 years were investigated. Group 1 comprised 20 subjects (10 males/10 females) with age of 20s; group 2 , 14 subjects (7 males/7 females) with age of 30s; group 3, 16 subjects (8 males/8 females) with age of 40s; and group 4, 16 subjects (8 males/8 females) with age of 50s. Mean SBRS at resting supine position was 5.3 짹 3.2 ms/mmHg and decreased to 5.3 짹 1.4 ms/mmHg during first 30 minutes after HUT and further decreased to 3.1 짹 1.4 ms/mmHg during later 30 minutes after HUT (p<0.001). Decrease in SBRS was significant at the transition from group 2 (< 40 years) to group 3 (��� 40 years). Younger group (< 40 years) had greater SBRS during resting supine condition (6.6 짹 3.5 vs. 4.0 짹 2.3, p<0.001), as well as during HUT (3.8 짹 1.4 vs. 2.9 짹 1.3, p=0.013). Conclusion: This study shows that elderly subjects have reduced SBRS throughout resting and orthostatic stress conditions.