Background Percutaneous coronary intervention (PCI) with drug-eluting stents (DES) may cause arteriopathy such as aneurysm formation, late stent malapposition, stent thrombosis and vessel rupture due to toxic effects on coronary arterial wall. However, the clinical and angiographic parameters of DES associated arteriopathy are not clarified yet. Methods A total 199 consecutive patients (pts, 299 stented segments) treated with Sirolimus- (SES) or Paclitaxel- (PES) eluting stents were enrolled. We compared the clinical and angiographic characteristics of pts with neo-aneurysm with those of the pts without neo-aneurysm at 6 months. Results The overall incidence of angiographic coronary neo-aneurysm was 2.3% (17/299 stented segment, mean age 60.5 짹 11.7, male 68.8%). Among the 17 neo-aneurysms, 10 were associated with SES and 7 PES. There were no significant differences in conventional risk factors and major baseline laboratory findings. However, pts with neo-aneurysm received more triple antiplatelet regimen at least for 1 month (aspirin + clopidogrel + cilostazol, 81.2 % vs aspirin + clopidogrel, 46.4%, p<0.01). The pre-PCI diameter stenosis was higher (83.8% vs 73.4%, p<0.05) and there was a trend toward longer lesion length (29.8mm vs 24.9mm, p=0.07) in pts with neo-aneurysm. Conclusion Triple antiplatelets including cilostazol, the higher diameter stenosis and the longer lesion length before PCI may be associated with the development of coronary neo-aneurysm after DES implantation.