Backgrounds:Continuous renal replacement therapy (CRRT) is often the preferred choice over intermittent renal replacement therapy in patients with cardiovascular compromise. But the in-hospital mortality rate of the patients performed CRRT is very high. So we investigated which predictors are associated with in-hospital mortality, especially in patients with critical cardiovascular diseases such as AMI or the sate of post-CABG. Methods:We analyzed 56 consecutive patients (mean age 63짹12 years, men 54.3%) who had critical cardiovascular diseases and were treated by CRRT. Vital signs, echocardiographic and laboratory data were compared between alive and dead groups. Then we analyzed the independent predictors of in-hospital mortality by multiple logistic regression analysis. Results:In-hospital mortality rate was 46.3%. In univariate analysis of two groups, there were statistical differences in mean systolic pressure before CRRT(alive vs. dead, 109짹16vs.96짹14, p=0.039), E/E(12짹3.5vs.26짹7.7, p=0.028), post-CRRT BUN(26짹9vs.35짹16, p=0.038) and post-CRRT albumin(3.0짹0.4 vs.2.7짹0.5, p=0.047). In multiple logistic regression analysis, E/E���(OR 1.869, CI 1.650-5.375, p=0.039) and mean systolic pressure(OR 0.396, CI 0.297-0.995, p=0.045) were independent predictors of in-hospital mortality. Especially, in dead group, there were no patients with normal diastolic function(E/E���<15)(figure). Conclusions:High E/E' is a good predictive cardiac function of in-hospital mortality in patients with critical cardiovascular diseases treated by CRRT.