Backgrouds:Although E/E��� are well known to be non-invasive parameters for estimating LV filling pressures, the accuracy for estimating it appear to be low especially in the patients with decreased left ventricular ejection fraction (EF<50%). Objective: This study was designed to evaluate the correlations of LAVi/A��� with pulmonary capillary wedge pressure (PCWP) and to compare those with the correlations of E/E��� and PCWP. Methods and Results: Fifty two consecutive patients in sinus rhythm (men,n=40: mean age, 54.5짹14.3 years) underwent right heart catheterization and comprehensive Doppler echocardiography simultaneously. 22 patients had lower ejection fraction (EF<50%) and 28 patients had higher E/E��� (E/E������15). In entire study population, the correlation coefficient of LAVi/A��� with PCWP is higher than that of E/E��� with PCWP (r= 0.68 vs. 0.55, respectively), which is largely attributable to the higher correlation coefficient of LAVi/A��� with PCWP in patients with normal LVEF (EF���50%) (0.714 vs. 0.372, respectively). In multiple linear regression analysis, we acquired the equation as follows: PCWP = 9.5 X Ln LAVi/A��� + 0.5 X E/E��� – 0.5 (r=0.73, r2= 0.54, p<0.001) Conclusion:A new echo index, LAVI/A��� is a useful parameter for estimating LV filling pressure in all levels of systolic function and combined interpretation of LAVi/A��� and E/E��� may give additional benefit to estimate PCWP. Especially, LAVI/A��� may be an more exact surrogate to assess LV filling pressure in patients with normal LV systolic function.