Backgrounds : Receptor for advanced glycation (RAGE) has been known to be associated with vascular inflammation in diabetic patients and soluble RAGE (sRAGE) reflects the expression of cell surface RAGE. So we investigated whether plasma sRAGE level is associated with in-stent restenosis (ISR) occured due to inflammatory process in diabetic patients who underwent percutaneous coronary intervention (PCI) by drug-eluting stent (DES). Methods : We enrolled 40 patients with ISR (Group I) and age- and sex-matched 40 patients without ISR (Group II) confirmed by follow-up coronary angiography (CAG) 6-12 months after first PCI. Mean age of both groups is 63.06짹10.27 years and 56 men(70%) were included. Blood sampling was performed at follow-up CAG and then the plasma level of sRAGE and Insulin like growth factor-1 (IGF-1) which was associated with ISR in bare metal stent (BMS) were measured by Enzyme-linked immunosorbent assay. Results : The baseline characteristics showed no difference between the groups. However, the plasma level of sRAGE was significantly higher in group I than that in group II (8652.02 짹 7422.48 pg/ml vs. 5891.96 짹 3104.76 pg/ml, p=0.039, respectively). On the contrary, the plasma levels of IGF-1 showed no difference between the groups (group I vs. group II:0.9208 짹 0.3016 vs. 1.0269 짹 0.3179 ng/ml, p=0.132). Conclusions : Our findings suggest that the RAGE axis may play more important role in ISR rather than IGF-1 axis in DES.