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ȣ - 520696 400 |
The impact of renal insufficiency on clinical outcomes after percutaneous coronary intervention in acute myocardial infarction |
계명대학교 동산병원 |
김인철, 허승호, 조윤경, 이현숙, 남창욱, 김형섭, 한성욱, 김윤년, 김권배 |
Backgrounds: The association between renal failure and coronary artery disease is well known. However, the impact of renal sufficiency undergoing percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) is not well established.
Methods: 917 patients (1233 lesions) who diagnosed as AMI and underwent PCI were included from March 2003 to July 2007. One year clinical events were evaluated according to baseline creatinine clearance (CrCl) using Modification of Diet in Renal Disease prediction equation (≥ 90, 60 to 89, 30 to 59 and < 30mL/min) or whether the patient was on dialysis.
Results: Patients with lower CrCl were more likely to be female, diabetic and hypertensive (all p<0.001). As the renal function was poorer, one-year mortality was more increased. See the below table of the details.
Conclusions: Despite of successful PCI, renal insufficiency is associated with an increased clinical events independent of other variables
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Normal (n=197) |
Mild RI (n=658) |
Moderate RI (n=316) |
Severe RI (n=62) |
P value |
Mean CrCl, mL/min |
101.5 |
74.9 |
51.2 |
18.7 |
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All-cause death (%) |
3 (1.5) |
22 (3.3) |
22 (7.0) |
15 (23.4) |
<0.001 |
Cardiac death (%) |
3 (1.5) |
11 (1.7) |
12 (3.8) |
5 (7.8) |
0.007 |
Myocardial infarction (%) |
4 (2.0) |
7 (1.1) |
10 (3.2) |
5 (7.8) |
0.002 |
Target lesion revascularization (%) |
9 (4.6) |
17 (2.6) |
9 (2.8) |
3 (4.7) |
0.454 |
Major adverse cardiac events (%) |
16 (8.1) |
41 (6.2) |
40 (12.7) |
14 (22.6) |
0.000 |
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