Backgrounds: Previous study showed that non-uniform circumferential stent strut distribution affected the local concentration of drug, which might be associated with increased intimal hyperplasia. However, there was no data about the difference of non-uniform stent distribution (NSD) between drug eluting stents (DES) which had similar stent cell design. The aim of this study is to evaluate the incidence of NSD and its effects between two open cell DES. Methods: From March 2003 to October 2007, intravascular ultrasound at post-intervention and follow-up was performed in 78 patients: 47 patients of paclitaxel-eluting stent (PES) and 31 patients of zotarolimus-eluting stent (ZES) with no or mild calcification. NSD was defined as angle of adjacent struts > 90 degree and % NSD was defined as the frame count of segments with NSD divided by frame count of stent length. Neointimal volume index (NIVI = neointimal volume/stent length) and major adverse cardiac events (MACE: cardiac death, myocardial infarction and target vessel revascularization (TVR)) were assessed at 12 months after the index procedure. Results: There was no significant difference in baseline characteristics between two groups. Although percent NSD was significantly larger in PES (4.75짹7.48% vs. 1.52짹3.49%, p=0.012), there was no difference in NIVI and MACE at 12months (Table). Conclusions: Although PES group showed more common NSD among two open cell DES, small percentage of NSD was not associated with neointimal hyperplasia or clinical outcomes.