Background : Chronic ventricular tachycardia is well-known as a cause of cardiomyopathy. Recently, it has been reported that even simple premature ventricular complexes(PVCs) can result in cardiac functional deterioration. However, whether PVC elimination can reverse the left ventricular(LV) dysfunction was not fully investigated. This study was undertaken to investigate the impact of radiofrequency catheter ablation(RFCA) of PVCs on cardiac function in the patients with chronic frequent PVCs. Methods and results : Twenty five patients who had received RFCA for chronic frequent PVCs were enrolled (Mean age; 43.6짹15.9 yrs, M:F=13:12). Before and more than 3 months after RFCA (Median follow-up duration; 440 days), cardiac function was evaluated with echocardiography. LV dimension and volume, LV ejection fraction(LVEF), left atrial volume index(LAVI) and Doppler mitral inflow velocity were measured. The averaged burden of PVCs was 22.1짹10.1% from the 24-hour Holter monitoring. Baseline left ventricular end-diastolic and end-systolic dimension (LVEDD, LVESD) and LV ejection fraction(LVEF) was 52짹5.9mm, 36짹6.2mm and 52짹6.5% respectively. After ablation, LVEDD and LVESD diminished and LVEF improved significantly (49짹5.0mm, p<0.01, 32짹4.8mm, p<0.01, 57짹6.6%, p<0.01, respectively). Beneficial LV reverse remodeling and improved LVEF were also observed in the patients with preserved EF (>50%, n=12). LAVI significantly decreased in the patients with the baseline LAVI larger than 35 ml/m2 (48.2짹11.2 ml/m2 vs 42.0짹11.6 ml/m2, p<0.01). E and E��� velocity decreased (62짹15.0 vs 55짹12.9, p=0.011, 8.3짹3.2 vs 7.2짹2.1, p=0.035) but the E/E��� and E/A ratio did not change at follow-up echocardiography Conclusion : The beneficial effects on reverse remodeling and cardiac function by RFCA in patient with frequent PVCs may be a indirect evidence that even repetitive isolated PVC���s can cause cardiomyopathy and active therapeutic approach is required in this subset of patients.