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ȣ - 520498 4 |
| Differences of Thromboembolic(TE) Risk According to Age in Korean Patients with Atrial fibrillation: Preliminary Report of Korean Atrial Fibrillation study(KORAF) |
| 전남대병원 심장센터 |
| 윤남식, 김영훈, 김유호, 김윤년, 김준수, 노태호, 박형욱, 신동구, 오동진, 오세일, 오용석, 이경석, 이문형, 정병천, 조용근, 조정관, 조정휘, 차태준, 최기준 외 Korean Atrial Fibrillation study investigators |
Background: Atrial fibrillation(AF) registration studies are not common relatively. Nationwide prospective AF registration studies are even rarer. KORAF was conducted by Korean society of circulation, in order to evaluate characteristics of Korean AF. Especially, this study was focused on age-factor. Method: Study population were 16403(64.1±14.70 year, 9623 males) AF patients, who were registered in KORAF from Nov 2005 to Oct 2007. Additional analysis of patients characteristics were done according to age. Result: Study population consisted of 2145(13.0%) first-detected AF, 7555(45.8%) paroxysmal AF, 2284(13.9%) persistent AF, 2730(16.6%) permanent AF, and 1776(10.8%) undefined AF. In old age over 70, incidences of hypertension, diabetes, congestive heart failure were higher, and incidence of mitral valve stenosis was lower than those in younger age. Treatment strategies were composed with 1727(10.5%) rhythm control and 6255(71.2%) rate control. Incidence of complication or adverse event was 19.7%. All cause death was 7.6%. Cardiac death was 3.3%. Myocardial infarction was 3.1%. Major bleeding was 4.9%. Minor bleeding was 15.5%. TE complication was 14.8%. Age of TE complication developers was higher than that of non-developers(67.9±11.63 years vs. 66.0±12.63 years, p<0.001). Incidences of hypertension, ischemic cerebral infarction, and mitral valve stenosis were higher in TE complication developers(47% vs. 43%, 52% vs. 17%, 61% vs. 33%, respectively). However, there was no difference of incidence of diabetes, congestive heart failure, compared to TE complication non-developers. 55% of TE complication developers had taken warfarin. Average INR was not different between groups (2.27±2.353 vs. 2.12±1.828, p=0.265). Interestingly, in older TE developers, only ischemic cerebral infarction history was higher than TE non-developers(54% vs. 22%, p<0.001). 46% of older TE complication developer had taken warfarin. Average INR was lower in TE complication developers(2.25±0.743 vs. 2.10±1.13, p=0.023). Conclusion: It is complex to clarify TE risk factors of Korean old aged patients with AF, compared to that of younger patients. Further analysis as multivariate analysis, follow-up data are needed.
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