Background and Objectives: The current lipid guideline and other several clinical trials have strongly recommended an low density lipoprotein (LDL) cholesterol level of less than 70mg/dL as the goal of therapy for patients with very high risk for coronary artery disease (CAD). However, in the era of drug-eluting stents (DES), there have been lacks of evidences that reduction of LDL cholesterol levels to 70mg/dL is associated with a better clinical outcome. In this study, we evaluate whether LDL cholesterol reduction, especially less than 70 mg/dL, would affect clinical outcomes in patients treated with DES. Subjects and Methods : From October 2003 through June 2006, 1141 patients were treated with DES due to CAD. Among them, we identified 471 patients who had not performed any DES implantation previously and had checked LDL level within 1 year after index procedure. These patients were divided into 2 groups based on the level of 1-year LDL cholesterol[Group A:follow-up LDL < 70mg/dL(n=178) vs. Group B:follow-up LDL ���70mg/dL(n=193)]. Then we analyzed the incidence of major adverse cerebrocardiovascular events[MACCE:death, myocardial infarction(MI), target vessel revascularization(TVR), cerebrovascular accidents(CVA)] of the both groups. Result: Mean follow-up duration was 30.77짹10.38 months. There was no significant difference of clinical and angiographic characteristics between 2 groups. The overall incidence of MACCE in group A [32 (18%) patients] was significantly lower than group B [83 (28.3%) patients, p=0.007]. Especially, the TVR was significant lower in group A (group A vs. group B = 11.2% vs. 21.2%, p=0.006). Among MACCE, target vessel revascularization(TVR) was significant lower in group A (group A vs. group B = 11.2% vs. 21.2%, p=0.006). However, there was no difference of overall mortality,MI or CVA between 2 groups. By multivariate logistic regression analysis, the only independent predictor for MACCE was follow-up LDL cholesterol < 70mg/dL (Odd ratio=0.56, 95% confidence interval : 0.29-1.08, p=0.011). Conclusion: This study demonstrates that lowering of the LDL cholesterol level below 70mg/dL in patients treated with DES is still the most important factor for the reduction of MACCE or TVR.