Background Patients with MS are considered to be associated with increased risk for cardiac events. But the impact of MS on ISR and long-term clinical events in patients underwent PCI isn't well defined. The objective of this study is to investigate the impacts of MS on the occurrence of ISRs, MACEs, TLRs during 36-months F/U. Methods and Results 338 patients having coronary lesions treated with stent from Jan 2002 to Dec 2004 were enrolled. 147 were treated with BMS(69 - patients with MS[group A], 78 - patients without MS[group B]) and 191 were treated with Sirolimus-eluting stents[SES](101 - patients with MS[group C], 90 - patients without MS[group D]). MS was defined according to NCEP ATP-��� criteria. The prevalence of MS was 50.3%(n=170) and the follow-up duration was median 26.8짹13.0 months. Baseline characteristics were comparable between the groups except for ATP-��� criteria compositions. The ISR rates were 31.9% in group A, 21.8% in group B(p=0.193) and 6.9% in group C, 5.6% in group D(p=0.918). The rates of MACEs and TLRs at 36 months were 46.4% in group A, 28.2% in group B(p=0.074) and 17.8% in group C, 13.3% in group D(p=0.641). Whereas bare-metal stent implantations were independent predictors of MACEs and TLRs (OR 3.08,95% CI 1.82~5.22,P<0.001) ConclusionPatients with MS had not an increased risk for ISRs, TLRs, MACEs compared with patients without MS.