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ȣ - 520138 60 |
| A carbohydrate fraction, AIP1, from Artemisia iwayomogi reduces the action potential duration by activation of delayed rectifier K+ channels in rabbit ventricular myocytes. |
| ¹ 인제대학교 의과대학 부산백병원 심장내과학교실, ² 인제대학교 의과대학 생리학교실 미토콘드리아생체신호-국가지정연구실, ³ 인제대학교 심혈관 및 대사질환 연구센터, FIRST 미토콘드리아 연구그룹 |
| 박원선² ³, 김성만¹ ³ , 손연경² ³ , 고은아² ³ , 김나리² ³ , 염재범² ³ , 한진² ³ , 박영진¹ , 노은지¹ , 한양천¹ , 김기훈¹ , 설상훈¹ , 양태현¹ , 김대경¹ , 김두일¹ , 김동수¹ ³ |
We investigated the effects of the hot-water extract from Artemisia iwayomogi (Compositae, AIP1) on cardiac ventricular delayed rectifier K+ current (Ik) by the patch clamp technique. The application of AIP1 increased coronary blood flow (CBF) and heart beatings in dose-dependent manner. 50 µg/ml AIP1 shortened the action potential duration (APD) without significantly affecting resting membrane potential. This effect was mediated by activating of Ik. The inhibition of rapidly activating delayed rectifier K+ current (Ikr) by E-4031, a specific inhibitor of Ikr completely blocked the effect of AIP1. In contrast to the marked inhibition of IKr, slowly activating delayed rectifier K+ current (IKs) was hardly affected by AIP1. AIP1 did not affect the coronary arterial tone and ion channels significantly even under the highest concentration of AIP1. These results could provide the novel clinical effect of natural product, AIP1 for treating long QT syndrome.
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