[Introduction] It remains still controversial whether the degree of effectiveness provided by sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) is similar in patients with diabetes and/or non diabetic populations. We investigated the long-term clinical outcomes of SES and PES in DES cohort of Seoul National University Hospital. [Methods] In this study, total 1790 patients (mean age 64짹10ys) who underwent PCI with drug eluting stent (DES) between February 2003 and June 2006, were analyzed. We investigated the clinical outcomes of 666 diabetic subgroup patients treated with either SES (n=446), or PES(n=220), and of 1124 non diabetic group patients (SES 766, PES 358). [Results] The rate of major adverse cardiac events (MACE) in diabetic patients during mean follow up duration of 21.8짹12.1 months (median 20.9 months), was similar between SES and PES (SES vs. PES; 21.7% vs. 22.3%, P = 0.878). The rate of target vessel revascularization (TVR) in diabetic patients was lower in SES group (SES vs. PES; 12.8% vs. 19.1%, P = 0.031, OR = 0.669, CI 0.465-0.964). However, the rate of MACE in non diabetic patients was significantly lower in SES group than in PES group (SES vs. PES; 11.4% vs. 17.0%, P = 0.009, OR = 0.667, CI 0.493-0.902). In a different aspect, the rate of MACE in SES group was significantly higher in diabetic group than in non diabetic group (21.7% vs. 11.4%, P < 0.001, RR = 1.915, CI 1.469-2.495) due to differences in cardiac death (5.6% vs. 1.8%, P < 0.001, RR = 3.067, CI 1.611-5.838) but the rate of MACE in PES group was not different between diabetics and non diabetic group (22.3% vs. 17.0%, P = 0.12). [Conclusions] The rate of MACE in non diabetic patients was significantly lower in SES group than in PES group. But the rate of MACE in diabetic patients was similar between SES and PES. It means that the superiority of SES in non diabetic group is attenuated in diabetics. In SES group, the rate of MACE was higher in diabetics than non diabetic group. In PES group, however, the rate of MACE was similar between diabetics and non diabetic group. These data suggest that PES is durable in diabetics.