Background: Little is known about the predictive value of N-Terminal pro-B-type natriuretic peptide (NT-proBNP) on repeat revascularization after percutaneous coronary intervention (PCI). Methods and Results: We analyzed clinical and angiographic data of 285 patients (mean age, 63 years; 72% male) with 364 target lesions who showed normal LV systolic function and no regional wall motion abnormalities before PCI and underwent successful coronary artery stenting. On admission for follow-up angiography, we measured NT-proBNP prior to angiography and investigated the association of NT-proBNP levels and repeat revascularization after PCI. Overall, NT-proBNP levels were significantly higher in patients with repeat revascularization (n=30) than patient without repeat revascularization (n=255) [114.1 pg/ml (53.1-236.1) vs. 47.7 pg/ml (21.3–89.1) P<0.05]. NT-proBNP values increased significantly with atherosclerotic risk factors such as, age, renal dysfunction, LDL cholesterol level and CRP (P<0.05). In multiple logistic regression analysis, NT-proBNP levels (>91 pg/ml) and diabetes were independent predictor for repeat revascularization (OR, 3.4; 95% CI, 1.33-8.38, P<0.05) but NT-proBNP showed relatively poor sensitivity (65%) and specificity (74%) in predicting repeat revascularization. In symptomatic patient, however, with 83.2 pg/ml as optimal cutoff value of NT-proBNP for repeat revascularization, the negative predictive value for repeat revascularization are 96%. Conclusions: This study shows that NT-proBNP levels are independent predictor for repeat revascularization. Although the predictive role of NT-proBNP is limited, low NT-proBNP level in symptomatic patient suggests less likely for repeat revascularization and it may be helpful in differentiate patients with risk for repeat revascularization.