Background: Cirrhotic cardiomyopathy(C-CMP) defined as blunted systolic and diastolic contractile responses to stress are more common in advanced liver cirrhosis (LC). It can aggravate complications of LC and also increase cardiovascular morbidity and mortality after liver transplantation. But screening methods for C-CMP are absent. This study was designed to define chronotrophic and inotropic response assessed by low (20關g/kg/min) and high-dose (40關g/kg/min) dobutamine stress echocardiography (DSE) in patients with advanced LC. Method: We enrolled consecutive 28 advanced LC (mean age; 49.4짹8.3 yrs) with Child-Pugh score > 5 and seven normal controls (mean age; 47.0짹10.8 yrs) underwent DSE. We measured ejection fraction (EF), LV end-diastolic volume (LVEDV) and end-systolic volume (LVESV) by modified Simpson���s method. Diastolic parameters (E/A ratio, and deceleration time) were also measured in baseline and high-dose. Blunted inotrop! ic and chronotrophic response defined to increment of EF and heart rate by less than 5% during dobutamine stress. Results: Demographic and echocardiographic findings were described as table. There was no adverse event during DSE. Conclusions: Our results showed 24.1 %( n=7) of patients with advanced liver cirrhosis showed blunted inotropic and chronotrophic response with diastolic dysfunction. Our results suggested DSE might be a useful and safe modality for screening of C-CMP.