Purpose: Hyperuricemia has been known as a risk factor for atherosclerosis. The metabolic syndrome (MS) is a predictor of adverse cardiovascular events. The contributions of the different components of the MS differ between genders. The aim of this study was to evaluate the association between serum uric acid (UA) and the variables of MS according to gender. Methods: We randomly recruited 675 subjects (373 men aged, 46.1짹9.5 yrs and 302 women aged 47.8짹11.6 yrs), who underwent health screening. The subjects were divided into 4 groups according to quartiles of serum UA. We measured the variable of MS including body mass index (BMI), blood pressure (BP), fasting blood glucose (FBS), HDL cholesterol (HDL), and triglyceride(TG). Results: The serum UA in men was significantly increased compared to in women (5.83  1.39 vs 4.08  0.95 mg/dL, respectively). The serum UA was correlated to BMI, systolic BP, HDL, TG, and number of variable of MS. In men, BMI, systolic BP, and TG showed a graded association with quartile of serum uric acid, but in women, BMI, HDL cholesterol, and TG did. Conclusions: The variables of MS had a different tendency to level of serum UA according to gender.