Background: The end-stage renal disease (ESRD) is generally known as a high risk for coronary artery disease. A few data are shown that ESRD is a predictor for adverse cardiac outcomes. We would like to evaluate the relationship with renal dysfunction and adverse clinical outcomes. Method: Six hundred two patients (male 68.3%, 851 lesions) were consecutively enrolled who underwent coronary intervention and checked creatinine clearance (CCr) since April 2003 to July 2005. All the patients were divided into three groups according to the degree of CCr: group 1 – CCr < 60, group 2 - CCr ��� 60. 12 months adverse clinical outcomes and 6 to 9 months angiographic follow-up results were analyzed. Results: Major adverse cardiac events were 5.7% in group 1, 8.2% in group 2. Other data are in the following table. 12months clinical follow-up was available in 95.4 %, angiographic follow up in 52.6 %. Conclusion: Renal dysfunction is a risk factor for all cause mortality. However, if we analyzed only cardiac death, there was no difference. Adverse outcomes in patients with renal dysfunction might be associated with noncardiac mortality.