Background: The treatment guideline for multiple vessel disease (MVD) is bypass surgery until now, especially in diabetes. However, MVD is traditionally a challenging target to interventional cardiologists. Drug-eluting stent (DES) had a great role in more complex coronary disease. We would like to evaluate the long-term clinical outcomes of coronary intervention according to the number of diseased coronary vessel. Method: Seven hundred twenty patients (male 67.1%, 882 lesions) were consecutively enrolled who underwent coronary intervention since April 2003 to July 2004. All the patients were divided into two groups according to the number of diseased coronary vessel: group 1 – one VD, group 2 – MVD. Left main disease and the lesions which were hard to deal with intervention were excluded according to operator���s decision. 24 months clinical outcomes and 6 to 9 months angiographic follow-up results were analyzed. Results: Major adverse cardiac events were 9.1 % in one VD, 8.1 % in MVD (p= 0.61). Other data are in the following table. 24 months clinical follow-up was available in 87.8 %, angiographic follow up in 51.2 %. Conclusion: Despite higher incidence of diabetes, long-term (2 year) clinical outcomes and follow-up angiographic results were not different. Optional coronary intervention in MVD could be tried in daily practice. In the near future, more complex and advanced coronary disease might be overcome by the support of DES.