학술대회 발표 연제 초록

Background: Alcohol may play an important role in the pathogenesis or clinical course of pts with vasospastic angina. Unlike the other conventional risk factors of coronary morbidity, the impact of alcohol and alcohl-related parameters including duration, frequency and amount of alcohol consumption on coronary artery endothelial dysfunction is not clarified yet. We investigated the incidence and characteristics of acetylcholine (Ach)-induced coronary artery endothelial dysfunction according to the alcohol and alcohol-related parameters. Methods: The study consisted of 1,086 patients (pts, Male 554, Age 56.38짹12.11 years) without significant coronary artery disease underwent Ach provocation test by injecting incremental doses of 20, 50 and 100 g to left coronary artery. Significant coronary artery endothelial dysfunction was defined as focal or diffuse severe transient luminal narrowing (>75%) with/without chest pain or ST-T change of EKG. Impact of conventional risk factors, alcohol and alcohol-related parameters on coronary artery endothelial dysfunction was analyzed. Results: Conventional risk factors of coronary atherosclerosis were not different between the groups except hyperlipidemia (31.7% vs. 68.3%, p=0.04) and smoking (35.6% vs. 64.4%, p<0.01) were higher in provocation (-) group. Although alcohol itself was not an independent predictor in provocation (+) results, there was a trend toward higher daily drinking amount and significantly higher frequency of drinking in provocation (+) group comparing with provocation (-) group (Table). Conclusion: Although alcohol was not an independent risk factor of significant Ach-induced coronary artery endothelial dysfunction but some alcohol-related parameters such as drinking frequency and amount might be associated with coronary artery endothelial dysfunction and relevant vasospastic angina.