학술대회 안내 사전등록 안내 초록등록 안내 초록등록/관리 숙박및교통 안내


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ǥ : ȣ - 500657   59 
Plasma NT-proBNP Levels and Risk Factors for Congestive Heart Failure in General Population based on a Large Cohort Study
연세대 원주의대 순환기 내과, 예방의학과¹
유병수, 이경훈, 안민수, 최현민, 김장영, 이승환, 윤정한, 최경훈, 고상백¹ , 박종구¹
Background: BNP or NT-proBNP levels may serve as a useful marker of cardiovascular risk in a screening setting of the general population. We evaluated that reference value and clinical usefulness of NT-proBNP at high risk of CHF within the Korean general population. Method: We included 3508 adult subjects (age; 40-69) of a community-based cohort from Korea Rural Genomic Cohort Study. Thorough biochemical and clinical data were recorded for all subject. The samples for NT-proBNP of 1,519 participants were assessed. In order to determine reference values, subjects having factors known to influence NT-proBNP levels were excluded. Also, to verify NT-proBNP testing for screening for subjects at high risk of CHF, we evaluated the relationship the clinical characteristics. Results: The characteristics of cohort are described as below; males: 41.2%, mean age: 54.8±8.4 years. The distribution of risk factors for CHF are hypertension (25%), LVH by ECG (15 %), hypercholestolemia (4.5%), smoking (32%), DM (10.9 %), history of coronary heart disease (4.9 %), history of CHF (0.9%) or with symptoms (6.1%), elevated serum Cr (≥1.5, 3.7%), obesity (40 %), respectively. The value of NT-proBNP of all subjects showed as below; mean 60.1, median 36.5 pg/mL. Also, the value of NT-proBNP of reference subjects (not having factors, n=224) showed as below; mean 40.8, median 32.1, minimum 5.0, maximum 296.2 pg/mL. There were no significant differences according to sex, smoking, DM, hypertension and ECG-LVH. But, in patients with history of CHF (58.5±103.29 vs. 213.8±258.8), severe obesity (62.4±119.3 vs. 52.1±61.9), old age (>60, 48.4 vs.84.2±139.5 pg/mL), BNP level was higher (p<0.05). Also, according to risk factors in CHF, patient with more than 3 factors had higher BNP levels (risk 0: 40.8±34.0, 1-2: 57.4±93.2, ≥3: 85.0±152.9 pg/mL). NT-proBNP levels were related to sex, BMI, urine albumin, serum Cr, and hs-CRP (p<0.05). Conclusions: We demonstrated the reference NT-proBNP value in Korean adult general population. The results of this study indicate that individuals with high NT-proBNP levels in the community have accumulating risk factors for CHF and related to the several risk factors.


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