학술대회 안내 사전등록 안내 초록등록 안내 초록등록/관리 숙박및교통 안내


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Determinants of Left Ventricular Mass Regression Following Aortic Valve Replacement for Pure Aortic Stenosis
성균관대학교 의과대학 내과학교실 삼성서울병원 심혈관센터 순환기내과¹ ,흉부외과 ²
박명준¹, 박승우¹, 양정훈¹, 김준형¹, 송영빈¹, 김학진¹, 신대희¹, 조성원¹, 이왕수¹, 최진오¹, 한주용¹,이상철¹, 이상훈¹, 홍경표¹, 박정의¹,성기익², 박표원²
Back Ground and Objectives Increased left ventricular mass (LVM) in patients undergoing aortic valve replacement(AVR) is associated with excess cardiac mortality and morbidity. The aim of the study is to investigate the determinant factors on LVM regression following AVR for pure aortic stenosis(AS). Method and Results In 193 patients undergoing AVR for AS, clinical and hemodynamic data were collected from their medical record retrospectively. Exclusion criteria included significant associated valvular disease to acquire pure AS patients. Echocardiography was performed preoperatively, early (7±3) days after AVR ('early') and (11±1) months (‘late’). After AVR, the LVMI regression was significant both at 'early' (142±46 vs. 157±46 g/m2, regression against preoperative value, P<0.001) and ‘late’ (112±41 vs. 142±46, against early value, P<0.001) evaluations. Multivariate analyses revealed that preoperative LVMI (P<0.001), preoperative transvalvular mean pressure gradient(mPG) of aortic valve (P=0.02) and mPG difference between the preoperative and the ‘late’ (P=0.004) showed significant influence on LVMI change, but age, sex, valve type, valve size, preoperative ejection fraction, diastolic LV internal diameter, relative wall thickness and atrial fibrillation had no significant influence. Conclusions LVM regression is significant both early 7 days and one year after AVR. Preoperative LVMI, preoperative transvalvular mPG of aortic valve and mPG change for one year after AVR are determinant factors on LVM regression following AVR for pure AS.


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