Introduction: The safety and efficacy of transcatheter PDA closure have been improved by recent evolutions and refinements of devices. Each device has its own merits and drawbacks. Methods: From February 2003 to February 2006, 138 patients (median age 2.9 years, median weight 13.0 Kg) underwent transcatheter closure of PDA. Our strategy for the device selection had been maintained throughout the study period; Gianturco coil, Cook detachable coil or small Nit-Occlud was used for a small ductus (Qp/Qs<1.5 or ductus diameter<2 mm, group 1, n=43) and medium to stiff Nit-Occlud (NO, group 2, n=49) or Amplatzer Duct Occluder (ADO, group 3, n=46) was selected for a moderate to large ductus, according to the size and morphology of each ductus. The immediate and follow-up results were evaluated and compared according to the types of devices. The Qp/Qs ratio, Pp/Ps ratio, and the minimum diameter(MD) of the ductus were also compared. Results: In all 138 patients (100%), complete occlusions were confirmed by follow-up echocardiography without any secondary implant. There was no complication other than 2 patients with temporary groin hematoma and/or weak arterial pulse. No device embolization, recanalization, hemolysis or newly developed vascular stenosis was observed. The Qp/Qs ratio, Pp/Ps ratio, and the MD were 1.18짹0.13, 0.25짹0.06, 1.91짹0.75 for the group 1, 1.74짹0.28, 0.26짹0.07, 3.02짹1.37 for the group 2, and 2.34짹0.81, 0.37짹0.18, 4.88짹1.75 for the group 3. Conclusions: A sophisticated strategy adopting the merits of various recent-generation devices for transcatheter PDA closure provides excellent clinical results with the lowest risk. Our findings are in favor of small coils for occluding small (Qp/Qs<1.5, MD around 2 mm) ducts, NO for moderate-sized (Qp/Qs=1.5-2.0, MD from 2 to 4 mm) ducts, and ADO for large (Qp/Qs>2.0 with MD>4 mm) PDAs.