Background : Rapid and effective hemostasis at femoral puncture sites minimizes both the hospital stay and patients��� discomfort. Therefore, a variety of arterial closure devices have been developed to facilitate the closure of femoral arteriotomy site. The objective of this study was to compare the efficacy and safety of two different closure devices; a collagen plug device (Angioseal짰) and a suture-mediated closure device (Perclose짰). Methods : From Jan 2005 to April 2006, a total of 1818 patients underwent vascular closure device application after coronary catheterization. Angioseal짰 was used in 426 and Perclose짰, in 1392 cases. The rates of successful hemostatis and complications were compared between 2 closure devices. The major complications were defined as follows: the need for vascular surgery, hemorrhage requiring transfusion, pseudoaneurysm, arteriovenous fistula, arterial occlusion or distal arterial embolism. Results : Successful hemostasis was achieved in 96.5% of the cases treated with Angioseal짰, and in 94.5% of the cases with Perclose짰 (p>0.05). The rates of major complications occurring between the two groups were not significantly different (1.17% in Angioseal짰, 0.72 % in Perclose짰, p=0.38). In the Perclose짰 group, 5 cases of late bleeding requiring transfusion and 5 femoral arterial occlusions occurred. In the Angioseal짰 group, 4 femoral artery occlusion and 1 case of retroperitoneal hemorrhage(surgically explored) occurred. On femoral artery angiogram of complicated case, mean minimal luminal diameter was 4.4짹0.9 mm. Multivariate analysis was performed using clinical and procedural characteristics. Only in female gender was identified as independently predictive of major vascular complications (OR 9.75, 95% CI 1.04-91.3). Conclusions : The efficacy and safety of two different closure devices were not different. Female gender was the only predictor for major vascular complication after closure device application.