학술대회 안내 사전등록 안내 초록등록 안내 초록등록/관리 숙박및교통 안내


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Diastolic dysfunction in young obese individuals is related to exercise intolerance.
서울대학교 의과대학 내과학 교실, 서울대학교병원 순환기 내과
윤창환, 강현재, 김용진, 김효수, 손대원, 오병희, 박영배, 최윤식
Backgrounds:Improvement of exercise capacity by training is more prominent in the obese individuals who have had sedentary life style. The aims of this study were to assess cardiovascular changes occurring in response to military training in young obese men. Methods: Sixteen obese (BMI>25 kg/m2), otherwise healthy subjects in age ranging from 20 to 21 years were enrolled. They completed the 5 weeks training which was consisted of aerobic and anaerobic exercise with increasing intensity. To assess exercise capacity, the running time of 1,500 m of each subject were measured before and after training. Serum metabolic markers and comprehensive echocardiograms were obtained at baseline and after 5 weeks of training. Results: Training significantly improved exercise capacity. Body mass index and body fat mass were reduced. Adiponectin was markedly increased with favorable changes of lipid profile. With marked improvement of exercise capacity, there were significant changes suggestive of improved diastolic function. Conclusion: Exercise elicited metabolic changes and improvement of diastolic function in young obese individuals, which suggests that diastolic dysfunction is related to exercise intolerance in obese individuals.

Before training

After training

Significance

Weight (kg)

86.4±4.3

80.1±3.5

<0.001

Height (cm)

176.3±3.4

1,500m record (sec)

382±11

359±14

<0.001

Body mass index(kg/m2)

27.7±0.8

25.5±0.6

0.001

Adiponectin (ηg/mL)

6853±1809

10500±2661

0.152

LV Ejection fraction (%)

60.5±2.5

57.9±2.1

0.042

Heart rate (/min)

78.4±5.4

58.8±4.2

<0.001

E/A

1.72±0.15

2.77±0.25

<0.001

E’ (cm/s)

14.0±1.5

14.1±0.9

0.768

A’ (cm/s)

6.5±0.4

4.8±0.4

<0.001

E/E’

6.3±0.6

7.0±0.5

0.050



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