[Purpose] : We investigated whether the coronary tissue factor (TF) levels are associated with tissue reperfusion status and BNP in acute STEMI patients subjected to primary coronary intervention. [Methods] : We performed primary PCI in 40 STEMI patients. Coronary blood was withdrawn by Thrombuster suction device. We measured plasma TF, CRP, BNP, troponin-T, and CK-MB levels. Initial and 120 min-later electrocardiogram were checked to examine the status of ST segment resolution. The patients divided into groups with higher (H group: above 10 pg/ml) and lower TF levels (L group : below 1 pg/ml). [Results] : H group showed significantly elevated initial BNP (210.36 + 251.65 vs 62.67 + 7.72 pg/ml, P=0.02) and lower LVEF on admission (43.8 + 7.72 vs 53.9 + 9.90 %, P=0.05). In addition, H group had less rapid resolution of ST segment as compared with L group. [Conclusion] : Acute STEMI patients with higher TF levels seem to have larger infarct area and show reduced tissure reperfusion following primary PCI.