Background: Carotid intima media-thickness(IMT) and N-terminal pro-BNP are established useful parameters for assessment of coronary artery disease. But the clinical significance of these parameters in patients with type 2 diabetes remains uncertain. Methods: Conventional transthoracic echocardiographic measurement, determination of N-terminal pro-BNP(NT-proBNP), B-mode carotid ultrasound and angiographic assessment were done in 380 patients(116 diabetes and 264 non-diabetes) with suspected coronary artery disease. Diabetic group included 56 patients without coronary lesion(mean age 64.3짹8.2 years) and 60 patients with coronary artery disease confirmed on angiography(mean age 64.9짹9.4 years). Non-diabetic group was consisted of 198 patients without coronary lesion(mean age 60.5짹10.4 years) and 66 patients with coronary artery disease confirmed on angiography(mean age 64.0짹9.7 years). Coronary artery disease on QCA analysis was defined as the presence of any luminal stenosis ���50%. Result: NT-proBNP, carotid IMT and the length of coronary stenotic lesion were significantly greater in Diabetic group than Non-diabetic group(1516.8짹6419.8pg/ml vs 362.7짹1110.6pg/ml, 1.36짹0.70mm vs 1.15짹0.54mm, 8.02짹11.67mm vs 4.96짹9.80mm, respectively, p<0.05). In non-diabetic groups, carotid IMT was significantly greater in patients with coronary artery disease than without coronary artery disease(1.23짹0.57mm vs 1.00짹0.30mm, p=0.005). In Diabetic group, however, carotid IMT was not different between in patients with CAD and without CAD(1.52짹0.85mm vs 1.19짹0.43mm, p=0.106). Conclusion: We conclude that carotid IMT and NT-proBNP are greater in patients with type 2 diabetes than non-diabetes. In contrast of non-diabetes, carotid IMT and NT-proBNP have limited role in predicting coronary artery disease in patients with type 2 diabetes.