Background and Objectives : Hyperuricemia is postulated to be a risk factor for atherosclerotic disease, although whether it is independent of classical atherogenic risk factors is controversial, but the relationship between serum uric acid (SUA) concentration and coronary artery disease(CAD) has not been fully investigated in a Korean population. Methods : We investigated in 1278 normal coronary angiographic group (516 men aged 54.4짹12.6 years and 762 women aged 59.3짹11.3 years) and 2854 CAD group (1832 men aged 60.5짹10.7 years and 1022 women aged 66.5짹9.0 years) treated with percutaneous coronary intervention. We first investigated the association between classical atherogenic risk factors and CAD, and then divided into 4 groups according to SUA quartiles. Results : In men, the mean SUA of normal group is 6.35짹3.74 and that of CAD is 6.17짹3.04, and in women, the mean SUA of normal group is 4.83짹1.60 and that of CAD is 5.35짹2.42. There were significant difference in women(p<0.001), but no in men between the groups. After adjusting for age, history of diabetes mellitus, smoking status, LDL-cholesterol, serum hsCRP level and history of high blood pressure, there were significant differences of age, diabetes mellitus, LDL-cholesterol and serum-hsCRP in men and except LDL-cholesterol in women. The odds ratios (95% CI) of sex-specific quartiles of SUA for CAD were 1.0, 0.603 (0.326-1.116), 0.875 (0.441-1.734), and 1.611 (0.694-3.737) in women, but it was not significantly different. Conclusion : CAD was increased according to SUA values only in women, but SUA was found not to be an independent risk for CAD.