IVUS-Virtual Histology (VH) using spectral and amplitude analyses of IVUS signal has demonstrated the potential to provide reliable quantitative information on plaque composition. We tried to find out that various types of remodeling coexisted within one coronary lesion, and to evaluate the difference of plaque tissue components according to coronary artery remodeling by each slices. A total of 656 cross-sectional slices of 20 severe (>75%) coronary lesions were examined. Measurements were made for the entire length of the lesion by 1.0mm interval. Positive remodeling was defined as a remodeling index >1.05, negative remodeling as <0.95, and intermediate (or no) remodeling as between them. Various types of remodeling coexisted within one coronary lesion (negative 49.8%, intermediate 24.1 %, positive26.1%, P<0.05). Fibrolipidic plaque occupied 31.27짹 6.19% of positively remodeled slices versus 16.40 짹14.10% of negatively remodeled slices (P <0.05). In negatively remodeled slices, there are more fibrotic, calcific, and necrotic plaques than in positively remodeled slices (58.37짹15.85, 11.72짹10.83, 13.50짹9.55 VS 51.80짹12.29, 6.37짹5.49, 10.56짹7.04 respectively, P <0.05). In conclusion, plaques with no remodeling, negative remodeling, and even positive remodeling coexisted within one coronary lesion and also directly correlated with plaque composition; In negatively remodeled slices, there are more fibrotic, calcific, and necrotic plaques, otherwise positively remodeled slices have more fibrofatty plaques.